Why do most cancers arise by bad luck, and can we prevent them? Dr. Siddhartha Mukherjee revisits his Emperor of All Maladies, covering inflammation, metabolism, CAR T therapy, KRAS inhibitors, and the idea of regenerative failure as a path to longevity. Roughly two-thirds of cancer-causing mutations appear random, but inflammation can turn dormant mutated cells into active tumors, according to Mukherjee's analysis.