Kevin Ryan, founder of MongoDB, Business Insider, and Zola, shares how to identify 10-year trends and build billion-dollar companies. From growing DoubleClick from 20 to 1,500 employees to co-founding AlleyCorp, Ryan reveals the frameworks he uses to spot emerging opportunities, avoid competitive commoditization, and recruit world-class talent. This episode covers trend analysis, the psychedelics market opportunity, nuclear energy investments, and lessons from both spectacular wins and costly failures. Bet on 10-year trends, not hype cycles, because building consequential companies requires a decade of execution; two-year trends leave you either too early or too late.