Neuroscientist Andrew Huberman discusses his 800-page book 'Protocols: An Operating Manual for the Human Body,' revealing how morning light exposure, cold exposure, and exercise create hormonal cascades that buffer stress throughout the day. He explains why knowledge alone doesn't protect against depression and suicide, shares stories of mentor deaths that shaped his mission, and explores how psychedelics, peptides, and AI are reshaping medicine while physicians gatekeep information. Spiking cortisol in the morning through sunlight, cold plunges, and exercise creates a hormonal buffer that blunts stress responses during the day and improves nighttime sleep quality.