David Cross reflects on 30+ years in comedy, from Boston's legendary scene to creating HBO's cult classic Mr. Show, navigating sitcom work on NewsRadio, and the creative process behind his latest special filmed in Athens. He discusses how stand-up remains his truest passion despite acting, writing, and producing careers. Stand-up comedy is non-negotiable for Cross; he would "go crazy" if unable to perform, unlike other creative pursuits he could abandon.